Protein Modification Reagents
Medchemexpress LLC PROTAC EGFR degrader 11 | 3034244-71-5 | 99.2% | 991.61 | 1 MG
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. It binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
- PROTAC degrader for epidermal growth factor receptor (EGFR).
- DC50 <100 nM.
- Binds CRBN-DDB1 with a Ki of 36 nM.
- Degrades EGFR, focal adhesion kinase (FAK), and RSK1.
- Inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
Medchemexpress LLC Protac Axl degrader 2 | 00-00-0 | 98.0% | 713.79 g/mol | C38H39N11O4 | 5 MG
PROTAC Axl Degrader 2 is a proteolysis targeting chimera designed to induce selective degradation of the Axl receptor tyrosine kinase for research applications. It is intended for in vitro studies of Axl biology and PROTAC-mediated protein degradation.
- Proteolysis targeting chimera (PROTAC) that induces selective degradation of the Axl receptor.
- Targets TAM family receptor tyrosine kinases via a PROTAC mechanism.
- Molecular formula C38H39N11O4 and molecular weight 713.79 g/mol.
- Purity approximately 98.0% as supplied.
- Recommended storage: protect from light and store under nitrogen; in solvent, -80°C for long-term, -20°C short-term.
- For research use only; not validated for clinical or therapeutic use.
Medchemexpress LLC PROTAC EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 25 MG
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.
- Potently inhibits EZH2 methyltransferase activity (IC50: 2.7 nM).
- Demonstrates anti-proliferative activity against human EOL1, MV4-11, Pfeiffer, RS4-11, and WSUDLCL2 cells.
- Inhibits cell viability in H128-LM, H128-BPM, H128 wildtype, and H128-Mut cells.
- Enhances sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
- Exhibits antitumor activity in H128-LM xenograft mouse models, prolonging survival when combined with Carboplatin, VP16, or VM26.
Medchemexpress LLC PROTAC BTK Degrader-10 | 2988804-46-0 | 771.91 | 5 MG
PROTAC BTK Degrader-10 is a PROTAC degrader for BTK. It can be used for research of chronic lymphocytic leukemia (CLL). It consists of a pink ligand for target protein (HY-170758), a black linker (HY-W392857), and a blue ligand for E3 ligase Cereblon (HY-W733176).
- PROTAC degrader for BTK
- Applicable for research on chronic lymphocytic leukemia (CLL)
Medchemexpress LLC PROTAC EGFR degrader 9 | 2992670-33-2 | 98.4% | 899.98 | 5 MG
PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. It demonstrates a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. This degrader exhibits potent degradation activity against various EGFR mutants while sparing EGFRWT. The compound is for research use only and not sold to patients.
- Orally active CRBN-based PROTAC EGFR degrader.
- Exhibits potent degradation activity against various EGFR mutants (EGFRL858R/T790M/C797S, EGFRdel19 T790M C797S, EGFRL858R/T790M, EGFRdel19).
- Spares EGFRWT.
- Inhibits NSCLC tumor growth in vivo without obvious toxicity.
- Reduces EGFR protein level and inhibits EGFR phosphorylation in tumor tissues.
- Arrests H1975-TM cells in the G0/G1 phase.
- Promotes cell apoptosis in H1975-TM cells.
eMolecules 2183440-32-4 | Medchem Express | APN-C3-PEG4-azide | 5mg | 779715127 | HY-140841 | 500.556 | C24H32N6O6
Ambeed | tert-Butyl 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylate | 100mg | 716529441 | A381595 | 474329-57-2 | MFCD11041977 | 386.246 | C15H20BrN3O4
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STA Pharmaceutical Fmoc-NH-PEG6-CH2COOH | 100 g | CAS 437655-96-4 | MDL MFCD26142983
Fmoc-NH-PEG6-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-96-4
- MDL: MFCD26142983
- InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
- Molecular Weight: 561.628
- Molecular Formula: C29H39NO10
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
- SMILES: O=C(NCCOCCOCCOCCOCCOCCOCC(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2
eMolecules 2055041-18-2 | Propargyl-PEG4-S-PEG4-t-butyl ester | Broadpharm | MFCD29918244 | 552.720 | C26H48O10S | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCC#C | 250mg | 306709058
Propargyl-PEG4-S-PEG4-t-butyl ester | Broadpharm | 2055041-18-2 | MFCD29918244 | 552.720 | C26H48O10S | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCC#C | 250mg | 306709058
Medchemexpress LLC Mal-PEG4-PFP ester | 1415800-42-8 | MFCD28556926 | 95.4% | 511.39 g/mol | C21H22F5NO8 | 250 MG
Mal-PEG4-PFP ester is a noncleavable antibody-drug conjugate (ADC) linker composed of a maleimide group, a four-unit polyethylene glycol (PEG4) spacer, and a pentafluorophenyl (PFP) ester reactive group. It is supplied as a viscous liquid for research use only and is not intended for therapeutic use.
- Noncleavable ADC linker suitable for conjugation strategies.
- Maleimide group enables thiol-selective conjugation.
- PFG ester (pentafluorophenyl) is reactive toward amines for efficient coupling.
- PEG4 spacer increases solubility and provides distance between conjugated components.
- High purity (95.4%) for research applications.
- Molecular weight 511.39 g/mol and formula C21H22F5NO8.
- Appearance viscous liquid, off-white to light brown.
- Recommended storage: pure form -20°C for long term; in solvent store cold as specified.